Thermo Fisher Scientific ARG1 Monoclonal Antibody (OTI4E6), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the final step of the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification processes. By degrading arginine, Arginase 1 limits nitric oxide synthase activity and downregulates nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, it is expressed in blood neutrophils but not in CCR3+ granulocytes. In mice, it is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may be expressed in myeloid cells infiltrating tumors and is typically detected in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.