Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI9F6), TrueMAB
베타카테닌 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합합니다. 인간 및 개 시료 반응성이 있으며, 액상 형태로 제공됩니다. 세포 접착 및 신호전달 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9F6 |
| Immunogen | Full-length human recombinant protein of human CTNNB1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the formation and maintenance of epithelial layers by regulating cell growth and adhesion. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links it to alpha-catenin, anchoring the E-cadherin complex to the actin cytoskeleton. It also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin is expressed in hair follicle cells and epithelial tissues. Dysregulation is implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, it co-activates Lef/Tcf transcription factors, promoting expression of genes such as cyclin D and c-myc that drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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