Thermo Fisher Scientific PI3K p85 alpha Monoclonal Antibody (6G10)
PI3K p85 alpha 단백질을 검출하는 Mouse monoclonal 항체로, Human 및 Mouse 시료에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합하며, Protein G로 정제된 1 mg/mL 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA517150
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6G10 |
| Immunogen | Purified recombinant fragment of human PIK3R1 (amino acids 159–388) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538621 |
Product Specific Information
MA5-17150 targets PIK3R1 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications, showing reactivity with Human and Mouse samples.
The immunogen is a purified recombinant fragment of human PIK3R1 (amino acids 159–388) expressed in E. coli.
MA5-17150 detects PIK3R1 with a predicted molecular weight of approximately 83.6 kDa.
Target Information
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein–coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter mediating the association of the p110 catalytic unit to the plasma membrane.
Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and mutations in this gene have been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in this gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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