Thermo Fisher Scientific PI3K p85 alpha Monoclonal Antibody (6G10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-17150 targets PIK3R1 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications, showing reactivity with Human and Mouse samples.
The immunogen is a purified recombinant fragment of human PIK3R1 (amino acids 159–388) expressed in E. coli.
MA5-17150 detects PIK3R1 with a predicted molecular weight of approximately 83.6 kDa.

Target Information

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein–coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter mediating the association of the p110 catalytic unit to the plasma membrane.

Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and mutations in this gene have been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in this gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.