Thermo Fisher Scientific DEDD2 Polyclonal Antibody
Rabbit에서 유래한 DEDD2 단백항체로 Western blot에 적합합니다. DEDD2 단백질의 129-149 잔기 합성 펩타이드로 면역화되었습니다. 세포 사멸 관련 연구용으로 사용되며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA522807
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 129–149 of the DEDD2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153832 |
Product Specific Information
- Suggested positive control: antigen standard for DEDD2 (transient overexpression lysate).
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (DED).
A novel DED-containing protein, DEDD2, has been identified. Overexpression of DEDD2 in transfected cells induces moderate apoptosis and sensitizes cells to apoptosis induced by Fas, TRAIL, and FADD.
DEDD2 can bind caspase-8 and -10 as well as FLIP, but not FADD. Similar to DEDD, DEDD2 translocates from the cytosol to the nucleus upon apoptosis induction, suggesting that DEDD2 may target caspase-8 to the nucleus and play a critical role in death receptor-induced apoptosis.
At least two alternatively spliced transcript variants encoding distinct isoforms have been identified for DEDD2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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