Thermo Fisher Scientific DEDD2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:100–1:2,000

Product Specifications

Product Specific Information

• Suggested positive control: antigen standard for DEDD2 (transient overexpression lysate).

Target Information

Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (DED).
A novel DED-containing protein, DEDD2, has been identified. Overexpression of DEDD2 in transfected cells induces moderate apoptosis and sensitizes cells to apoptosis induced by Fas, TRAIL, and FADD.
DEDD2 can bind caspase-8 and -10 as well as FLIP, but not FADD. Similar to DEDD, DEDD2 translocates from the cytosol to the nucleus upon apoptosis induction, suggesting that DEDD2 may target caspase-8 to the nucleus and play a critical role in death receptor-induced apoptosis.
At least two alternatively spliced transcript variants encoding distinct isoforms have been identified for DEDD2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.