Thermo Fisher Scientific EAPP Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human EAPP. Recombinant protein control fragment (Product #RP-89046). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:EAPP,uniProtId:Q56P03-1,ncbiNodeId:9606,antigenRange:32-142,antigenLength:285,antigenImageFileName:PA5-51774_EAPP_Q56P03-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51774_EAPP_Q56P03-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640862

Product Specific Information

Immunogen sequence: VLLHGTPDQK RKLIRECLTG ESESSSEDEF EKEMEAELNS TMKTMEDKLS SLGTGSSSGN GKVATAPTRY YDDIYFDSDS EDEDRAVQVT KKKKKKQHKI PTNDELLYDP E

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

Target Information

This protein may play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The C-terminal of EAPP binds the N-terminal of E2F1 and also interacts with E2F2 and E2F3, but not E2F4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.