Thermo Fisher Scientific OPHN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human OPHN1. Recombinant protein control fragment (Product #RP-92171). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OPHN1,uniProtId:O60890-1,ncbiNodeId:9606,antigenRange:580-687,antigenLength:802,antigenImageFileName:PA5-51775_OPHN1_O60890-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51775_OPHN1_O60890-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644988

Product Specific Information

Immunogen sequence: RVTARRHKPI TISKRLLRER TVFYTSSLDE SEDEIQHQTP NGTITSSIEP PKPPQHPKLP IQRSGETDPG RKSPSRPILD GKLEPCPEVD VGKLVSRLQD GGTKITPK

Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.

Target Information

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.