Thermo Fisher Scientific LRP5 Monoclonal Antibody (1E9)
Human LRP5 단백질을 인식하는 Mouse monoclonal antibody. Western blot 및 ELISA에 최적화. Affinity chromatography로 정제된 액상 형태. PBS 버퍼에 보존제 없이 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- H00004041-M01
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E9 |
| Immunogen | LRP5 (NP_002326.1, 41 a.a. approximately 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RDVRLVDAGG VKLESTIVVS GLEDAAAVDF QFSKGAVYWT DVSEEAIKQT YLNQTGAAVQ NVVISGLVSP DGLACDWVGK KLYWTDSETN
Target Information
LDL-related proteins LRP5 and LRP6 are members of the LDL receptor superfamily involved in the canonical Wnt signaling pathway.
Mammalian LRP6 binds to Wnt1 and enhances Wnt-induced developmental processes in Xenopus embryos.
Mice lacking LRP6 show developmental defects similar to those caused by deficiencies in various Wnt proteins.
Wnt proteins induce the binding of LRP5 to Axin, leading to Axin degradation and beta-catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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