Thermo Fisher Scientific SLC1A6 Polyclonal Antibody

Thermo Fisher Scientific SLC1A6 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MSSHGNSLFL RESGQRLGRV GWLQRLQESL QQRALRTRLR LQTMTLEHVL RFLRRN
• Highest antigen sequence identity to orthologs:
  Mouse - 80%, Rat - 80%

Target Information

Slc1a6 encodes a protein that functions as a glutamate transporter, part of the excitatory amino acid transporter (EAAT) family. These sodium- and potassium-dependent transporters are widely distributed throughout the brain and play a key role in the uptake of L-glutamate, L-aspartate, and D-aspartate.
SLC1A6 acts as a symporter transporting one amino acid molecule with two or three Na⁺ ions and one proton, coupled with the counter-transport of one K⁺ ion. It also mediates Cl⁻ flux to prevent charge imbalance during transport.
This transporter contributes to the rapid removal of glutamate from the synaptic cleft, essential for terminating postsynaptic signaling.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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