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Thermo Fisher Scientific Chk1 Polyclonal Antibody
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Human Chk1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA, IP 등 다양한 응용 가능. 보존제가 없는 액상 형태이며 Protein A 및 항원 친화 크로마토그래피로 정제됨. DNA 손상 반응 연구 및 세포 주기 조절 관련 연구에 적합.
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- pk
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마지막 업데이트 2025. 08. 05. 오후 12:48
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Thermo Fisher Scientific PA580475 Chk1 Polyclonal Antibody 100 ul pk판매 단위 pk ·
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424,300원VAT 포함 466,730원
Thermo Fisher Scientific · Thermo Fisher Scientific Chk1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,500–1:50,000 |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Chk1 Protein (Met1–Thr476) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787788 |
Product Specific Information
- Preservative-free formulation.
- Recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
- Specific for Human Chk1.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in maintaining DNA integrity by halting replication when damage occurs. It acts as a key mediator in the DNA damage-induced checkpoint network. When CHK1 function is inhibited, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells arrest in G1 phase. Therefore, CHK1 is an important target for cancer therapy, particularly in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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