Thermo Fisher Scientific GeneChip Cynomolgus Gene 1.0 ST Array, 30 arrays

Applied Biosystems™ GeneChip™ Cynomolgus Gene 1.0 ST Array

The GeneChip™ Cynomolgus Gene 1.0 ST Arrays enable you to:

• Measure gene expression across the entire transcript with higher resolution and accuracy than classical 3’-biased microarray solutions
• Obtain accurate and reproducible data using multiple independent measurements for each transcript

Background

Model and applied research organisms are essential for comparative genomics, evolutionary biology, and understanding molecular mechanisms underlying human disease and agricultural improvement.
The GeneChip Gene 1.0 ST Arrays were developed for a wide range of such organisms, offering whole-transcript coverage.
These arrays were designed in collaboration with leading researchers, including Alan Archibald (Roslin Institute), Leonard Zon, and Yi Zhou (Harvard Medical School).

Key Benefits

• Highest transcript coverage – up to 26 probes per transcript for reliable expression measurements
• Whole-transcriptome analysis – captures transcript isoforms often missed with 3’-biased designs
• High data correlation – inter- and intra-array signal correlation (R > 0.99) ensures consistency

Proven Performance

The GeneChip Gene 1.0 ST Arrays provide comprehensive transcriptome coverage for model and applied research organisms.
Each design incorporates the latest genomic information, enabling accurate detection of splice variants, non-polyadenylated transcripts, and truncated transcripts that may be missed by 3’-biased arrays.

Complete System Integration

For optimal performance, the Gene 1.0 ST Array is part of a complete solution including:

• GeneChip WT Sense Target Labeling and Control Reagents – for sample preparation and labeling
• GeneChip Fluidics Station 450 – automated array processing for reproducibility
• GeneChip Scanner 3000 7G – high-resolution image acquisition with optional Autoloader

Supporting tools for data analysis include:

• Expression Console Software – for probe summarization and quality evaluation
• NetAffx Analysis Center – comprehensive annotation and probe sequence database
• Integrated Genome Browser (IGB) – visualization of expression data in genomic context

Workflow

The data analysis workflow follows a process similar to 3’ gene expression analysis, utilizing Expression Console 1.1, third-party compatible software, and NetAffx annotation tools integrated with IGB.

Content Profile

GeneChip Gene 1.0 ST Arrays provide the latest coverage of the transcribed genome.
Each transcript is interrogated by up to 26 unique 25-mer probes, covering up to 650 bases per transcript.
This extensive probe coverage ensures superior data confidence and adaptability as genomic knowledge evolves.

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