Thermo Fisher Scientific Bestrophin-1 (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C, protected from light, for up to 1 week.
For longer storage, aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

The retinal pigment epithelium (RPE) and choroid form a system essential for retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant disorder characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
Mutations in the Bestrophin gene cause this disease. Bestrophin encodes a protein with four transmembrane domains, located at the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium.
Missense mutations at the Bestrophin locus reduce or abolish Bestrophin-mediated membrane current.
The human Bestrophin gene encodes a 585-amino-acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.