Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI12C1), TrueMAB
Beta-catenin 단백질을 인식하는 Mouse monoclonal 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. Human, Dog, Rat에 반응하며, Lyophilized 형태로 제공됩니다. 세포 간 접착 및 Wnt 신호전달 연구용에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12C1 |
| Immunogen | Full length human recombinant protein of human CTNNB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and regulation of epithelial layer formation. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless.
It is expressed in various hair follicle cell types and epithelial cells, and plays a role in tumorigenesis of tissues including colon, liver, lung, and skin. In the nucleus, it co-activates Lef/Tcf transcription factors that regulate genes promoting cell proliferation (e.g., cyclin D, c-myc).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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