Thermo Fisher Scientific Bcl-2 Polyclonal Antibody
Human Bcl-2 단백질을 표적하는 Rabbit Polyclonal 항체로, apoptosis 연구에 적합. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 Protein A 및 Antigen affinity chromatography 정제. 장기 보관 시 -20°C에서 안정적 유지.
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Thermo Fisher Scientific Bcl-2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View publications |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 75–110 amino acids from human Bcl-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.0 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2227962 |
Product Specific Information
This antibody is predicted to react with bovine based on sequence homology.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family dimerize to modulate apoptosis. Bag1 forms a heterodimer with BCL-2 enhancing its anti-apoptotic effect, while Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis. Overexpression or translocation of BCL-2 is associated with follicular lymphoma and other cancers such as B-cell lymphoma and prostate cancer. Two transcript variants differ in their C-terminal ends.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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