Thermo Fisher Scientific c-Abl Polyclonal Antibody
Rabbit polyclonal antibody recognizing human c-Abl (ABL1) protein. Validated for IHC, ELISA, and IP applications. Supplied as liquid form, 3 mg/mL, Protein G purified. Suitable for research on cell signaling, differentiation, and oncogene studies.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000–1:2,000 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Tyrosine-protein kinase ABL1 (amino acids 4–194) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | −20°C or −80°C (preferred) |
| Shipping Conditions | Wet ice |
| RRID | AB_3091526 |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. The c-Abl protein’s activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. CDC2-mediated phosphorylation regulates the DNA-binding activity of ABL1, linking it to cell cycle control. In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), a (9;22) chromosomal translocation creates the Philadelphia chromosome, fusing c-Abl from chromosome 9 with the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the transforming gene of Abelson murine leukemia virus (A-MuLV). c-Abl may also regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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