Thermo Fisher Scientific AIFM1 Monoclonal Antibody (OTI4E6), TrueMAB
AIFM1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 세포자멸사 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 134–483 of human AIFM1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Apoptosis Inducing Factor (AIF) induces chromatin condensation and DNA fragmentation during apoptosis.
AIF is localized in mitochondria and translocates to the nucleus upon apoptosis induction, promoting the release of apoptogenic proteins such as cytochrome c and caspase-9.
It is highly conserved between human and mouse and is widely expressed.
Mutations in the AIF gene are associated with combined oxidative phosphorylation deficiency 6, leading to mitochondrial encephalomyopathy.
Alternative splicing results in multiple transcript variants, and a related pseudogene exists on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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