Thermo Fisher Scientific BBS9 Polyclonal Antibody
인간 BBS9 단백질을 인식하는 Rabbit Polyclonal 항체입니다. IHC(P)에서 1:100~1:200 희석으로 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of human BBS9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636762 |
Product Specific Information
This antibody detects endogenous levels of total PTHB1 / BBS9 protein.
Target Information
The BBSome complex functions as a coat complex required for sorting specific membrane proteins to the primary cilia. It is essential for ciliogenesis but not for centriolar satellite function. This function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and interacts with the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. The BBSome associates with the ciliary membrane, binds to RAB3IP/Rabin8 (the GEF for Rab8), and facilitates Rab8-GTP localization to the cilium, promoting docking and fusion of carrier vesicles to the base of the ciliary membrane. Proper BBSome complex assembly and ciliary localization depend on this process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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