Thermo Fisher Scientific Complement C9 Polyclonal Antibody
Thermo Fisher Scientific의 Complement C9 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 비결합형 액상 항체로, 장기보관 시 -20°C에서 보관. C5b-9 복합체 연구에 적합한 고품질 연구용 항체.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 134–441 of Human C9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.62 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546569 |
Product Specific Information
- Recommended positive controls: THP-1, BCL-1, human plasma
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b, which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9, accompanying insertion of the complex into the cell membrane.
During formation of C5b-8 and C9 polymerization, neoantigens are generated that are unique to the C5b-9 complex and not present on any individual native components.
Complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive.
C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex formation is abrogated.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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