Thermo Fisher Scientific Complement C9 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: THP-1, BCL-1, human plasma
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b, which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9, accompanying insertion of the complex into the cell membrane.
During formation of C5b-8 and C9 polymerization, neoantigens are generated that are unique to the C5b-9 complex and not present on any individual native components.
Complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive.
C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex formation is abrogated.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.