Thermo Fisher Scientific MERS Coronavirus Spike Protein S1 Polyclonal Antibody

Thermo Fisher Scientific MERS Coronavirus Spike Protein S1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:5,000

Product Specifications

Product Specific Information

Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, add 50% glycerol, aliquot, and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

The spike (S) glycoprotein of coronaviruses contains protrusions that bind to specific receptors on host cells, essential for host specificity and viral infectivity.
The term peplomer refers to a grouping of heterologous proteins on the virus surface that function together.
The spike (S) glycoprotein of coronaviruses mediates virus binding and entry during infection.
The SARS-CoV spike (S) glycoprotein alone can mediate membrane fusion required for virus entry and cell fusion.
It is a major immunogen and a target for entry inhibitors.
The SARS-CoV spike (S) protein has two subunits:

• S1 subunit: contains receptor-binding domain engaging ACE2 receptor
• S2 subunit: mediates fusion between viral and host cell membranes

The S protein plays key roles in inducing neutralizing antibody and T-cell responses, as well as protective immunity during infection.

Usage Note

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.