Thermo Fisher Scientific DAND5 Monoclonal Antibody (OTI3D4), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The DAND5 gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers.
The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring.
The antagonistic effect of the secreted protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may regulate organogenesis, body patterning, and tissue differentiation.
In mouse, DAND5 binds Nodal and inhibits the Nodal signaling pathway that patterns left/right body asymmetry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.