Thermo Fisher Scientific GABRA6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 51 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A receptor (GABA-A R) subtype.
GABA-A Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.

The GABA-A receptor is a multimeric subunit complex composed of six alpha, four beta, and four gamma subunits, along with alternative splicing variants. Expression of alpha and beta subunits results in functional GABA-A receptors sensitive to GABA, while coexpression with a gamma subunit is required for benzodiazepine modulation.
Different alpha subunits may mediate various benzodiazepine effects in the brain, and phosphorylation of beta subunits modulates receptor function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.