Thermo Fisher Scientific GABRA6 Polyclonal Antibody
Rabbit polyclonal antibody targeting GABRA6, validated for WB. Detects endogenous 51 kDa protein. High purity (>95%) and antigen affinity purified. Suitable for research on GABA-A receptor function and related neurological studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 66–121 of human GABAA R alpha6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553601 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 51 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABA-A receptor (GABA-A R) subtype.
GABA-A Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents, and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABA-A receptor is a multimeric subunit complex composed of six alpha, four beta, and four gamma subunits, along with alternative splicing variants. Expression of alpha and beta subunits results in functional GABA-A receptors sensitive to GABA, while coexpression with a gamma subunit is required for benzodiazepine modulation.
Different alpha subunits may mediate various benzodiazepine effects in the brain, and phosphorylation of beta subunits modulates receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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