Thermo Fisher Scientific Phospho-TAB1 (Ser438) Polyclonal Antibody
인산화된 Ser438 부위의 TAB1 단백질을 특이적으로 인식하는 폴리클로날 항체입니다. Western blot 및 IHC(P) 분석에 적합하며, 인간, 마우스, 랫트 시료에서 반응합니다. 고순도 정제 및 안정한 PBS/glycerol buffer로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB1 (Accession Q15750), corresponding to amino acid residues around phosphorylated Ser438. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903220 |
Product Specific Information
This antibody detects endogenous levels of TAB1 only when phosphorylated at Ser438.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminus can act as a dominant-negative inhibitor of TGF beta signaling. TAB1 can also interact with and activate MAPK14 (p38α), providing an alternative activation pathway contributing to MAPK14-mediated responses.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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