Thermo Fisher Scientific P53 Monoclonal Antibody (UMAB206), UltraMAB
인간 p53 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC, ChIP 등 다양한 응용에 사용 가능. 고순도 친화 크로마토그래피 정제 제품으로, PBS/BSA/glycerol buffer에 보관. 세포 스트레스 반응 및 종양 억제 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB206 |
| Immunogen | Full length human recombinant protein of human TP53 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon activation, p53 induces transcription of target genes such as p21waf1, leading to G1 or G2/M arrest.
Structurally, p53 contains:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization. p53 functions as a key regulator preventing proliferation of damaged cells and acts as an anticancer agent. Alterations or mutations in the TP53 gene are common in human cancers and can lead to loss of tumor suppressor activity, contributing to malignancy. Additionally, p53 is implicated in aging, oxidative stress, and neuronal function, including long-term potentiation (LTP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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