Thermo Fisher Scientific Phospho-BRCA1 (Ser1280) Polyclonal Antibody
BRCA1 단백질 Ser1280 인산화 부위를 인식하는 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 인간에 반응하며, 항원 친화 크로마토그래피로 정제된 액상 형태. 유전자 안정성 연구 및 암 관련 단백질 분석에 적합.
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Thermo Fisher Scientific Phospho-BRCA1 (Ser1280) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunoprecipitation (IP) | 2.5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide representing a portion of human BRCA1 around serine 1280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Monkey and Chimpanzee
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC (BRCA1 associated genome surveillance complex) and interacts with RNA polymerase II and histone deacetylase complex.
BRCA1 is involved in transcription regulation, DNA double-strand break repair, and recombination. Mutations in BRCA1 account for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.
Alternative splicing affects its localization and function; several transcript variants have been identified, including disease-associated mutations. A related pseudogene is located on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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