Thermo Fisher Scientific IP3 R2 Polyclonal Antibody
Rabbit polyclonal antibody specific for human IP3 receptor isoform 2. Validated for WB and IHC applications. Lyophilized form without preservative. Suitable for research use in calcium signaling studies. Store at 4°C or -20°C for long-term stability.
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Thermo Fisher Scientific IP3 R2 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:300–1:2,000
- Immunohistochemistry (IHC): 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 1150–1200 of human IP3 receptor isoform 2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: IP3 R2.
Target Information
Inositol 1,4,5-trisphosphate (IP3) acts as a second messenger for numerous growth factors, hormones, and neurotransmitters. Upon binding to the IP3 receptor (IP3R), IP3 induces the release of luminal calcium into the cytosol. The IP3R functions as a homo- or heterotetramer of ~240 kDa glycoprotein subunits and is structurally and functionally related to the ryanodine receptor. Both receptors can associate with the immunophilin protein FKBP12, influencing calcium release through phosphorylation and dephosphorylation mechanisms involving PKC and calcineurin. Mammalian IP3R subunits are encoded by three distinct genes with differential expression patterns:
- IP3R-I: heart, liver, kidney, ovary, cerebellar Purkinje neurons
- IP3R-II: brain
- IP3R-III: pancreatic islets, kidney, gastrointestinal tract
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품 관련 이미지 파일명: OST00429W-100UL_IP3_Receptor_2_Q14571-1_Rabbit.svg, OST00429W-100UL_IP3_Receptor_2_Q14571-1_Rabbit_PDP.jpeg)
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