Thermo Fisher Scientific CDCA8 Polyclonal Antibody
CDCA8 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 사용 가능. Human 시료 반응성, 항원 친화 크로마토그래피로 정제됨. 세포 분열 및 암 관련 연구에 적합한 고품질 연구용 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDCA8. Recombinant protein control fragment (Product #RP-94216). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639580 |
Product Specific Information
Immunogen sequence:
LRTPAAGERI YNISGNGSPL ADSKEIFLTV PVGGGESLRL LASDLQRHSI AQLDPEALGN IKKLSNRLAQ ICSSIRTHK
Antigen sequence identity:
Mouse – 81%, Rat – 82%
Target Information
CDCA8 is a component of the chromosomal passenger complex (CPC), essential for the stability of the bipolar mitotic spindle. The CPC, which includes Survivin, CDCA8, INCENP, and Aurora-B, plays crucial roles during mitosis and cell division. CDCA8 expression increases during the G2/M phase and decreases after exit from M phase. It is cell cycle regulated, down-regulated by p53/Rb signaling, and up-regulated in various cancers. Inactivation of CDCA8 leads to polyploidy and delayed mitosis, highlighting its importance in cell proliferation. Aberrant expression is associated with poor prognosis in gastric cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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