Thermo Fisher Scientific OTX2 Polyclonal Antibody
OTX2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC(파라핀 절편)에 적합. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며, PBS/50% glycerol에 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OTX2 (Accession P32243), corresponding to amino acid residues D200–F250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900334 |
Product Specific Information
Antibody detects endogenous levels of total Otx2.
Target Information
OTX2 is a 289 amino acid protein belonging to the bicoid sub-family of homeodomain-containing transcription factors. It has two known alternative splice variants with distinct isoforms, though other isoforms cannot be excluded. OTX2 is an early marker of endodermal differentiation of embryonic stem cells and may play a role in brain and sensory organ development. The protein may bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Defects in OTX2 are associated with microphthalmia syndromic type 5 (MCOPS5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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