Thermo Fisher Scientific Placental Alkaline Phosphatase Monoclonal Antibody (5B1)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Radioimmune Assays (RIA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5B1

Immunogen

Purified human placenta ALP if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Placental Alkaline Phosphatase,uniProtId:P05187-1,ncbiNodeId:9606,antigenRange:1-535,antigenLength:535,antigenImageFileName:MIA1802_Placental_Alkaline_Phosphatase_P05187-1_House_mouse.svg,antigenImageFileNamePDP:MIA1802_Placental_Alkaline_Phosphatase_P05187-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11152999

Product Specific Information

MIA1802 targets Alkaline Phosphatase in ELISA, IP, and RIA applications and shows reactivity with Human samples.

The MIA1802 immunogen is purified human placenta ALP.

MIA1802 detects Alkaline Phosphatase which has a predicted molecular weight of approximately 59 kDa.

MIA1802 was formerly sold as a Seradyn product.

Target Information

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.