Thermo Fisher Scientific PDE12 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PDE12. Recombinant protein control fragment (Product #RP-100240). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PDE12,uniProtId:Q6L8Q7-1,ncbiNodeId:9606,antigenRange:494-586,antigenLength:609,antigenImageFileName:PA5-60267_PDE12_Q6L8Q7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60267_PDE12_Q6L8Q7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645323

Product Specific Information

Immunogen sequence: CGDFNSTPST GMYHFVINGS IPEDHEDWAS NGEEERCNMS LTHFFKLKSA CGEPAYTNYV GGFHGCLDYI FIDLNALEVE QVIPLPSHEE VTT

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 97%.

Target Information

PDE12 is an enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3,5`-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.