Thermo Fisher Scientific SNAI2 Monoclonal Antibody (OTI2F3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Slug (SNAI2) is a member of the Snail family of C2H2-type zinc finger transcription factors. It plays a key role in epithelial-mesenchymal transition and neural tube formation during vertebrate embryogenesis. Slug transcription is induced by growth factors such as FGF, BMP, and TGF-beta. It binds E-box regions of promoters and represses transcription of genes like E-cadherin and Claudin-1.
Its expression in breast, esophageal, and colorectal carcinomas is correlated with poor prognosis. Slug also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.