Thermo Fisher Scientific Phospho-Tau protein (Ser214) Polyclonal Antibody
Tau 단백질의 Ser214 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A로 정제된 고순도 항체로 안정적인 액상 형태. Alzheimer’s disease 연구 등 신경퇴행성 질환 연구에 적합.
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Thermo Fisher Scientific Phospho-Tau protein (Ser214) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Tau protein isoform TauF around the phosphorylation site of Ser214 [TP(p-S)LP] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, acting as a linker between both. Axonal polarity is influenced by Tau/MAPT localization within neuronal cells.
Hyper-phosphorylated Tau is the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease brains. This modification impairs Tau’s microtubule-binding ability, leading to microtubule destabilization and neuronal degeneration. Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Abnormal Tau phosphorylation is also associated with other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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