Thermo Fisher Scientific CD1A Monoclonal Antibody (M1-2-1B5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

M1-2-1B5

Immunogen

CD1A (AAH31645, 1 a.a. approximately 311 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD1a,uniProtId:P06126-1,ncbiNodeId:9606,antigenRange:1-327,antigenLength:327,antigenImageFileName:H00000909-M01_CD1a_P06126-1_House_mouse.svg,antigenImageFileNamePDP:H00000909-M01_CD1a_P06126-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MWNWLKEPLS FHVIWIASFY NHSWKQNLVS GWLSDLQTHT WDSNSSTIVF LWPWSRGNFS NEEWKELETL FRIRTIRSFE GIRRYAHELQ FEYPFEIQVT GGCELHSGKV SGSFLQLAYQ GSDFVSFQNN SWLPYPVAGN MAKHFCKVLN QNQHENDITH NLLSDTCPRF ILGLLDAGKA HLQRQVKPEA WLSHGPSPGP GHLQLVCHVS GFYPKPVWVM WMRGEQEQQG TQRGDILPSA DGTWYLRATL EVAAGEAADL SCRVKHSSLE GQDIVLYWEH HSSVGFIILA VIVPLLLLIG LALWFRKRCF C

Target Information

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan`s cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.