Thermo Fisher Scientific PTPRS Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human PTPRS if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PTPRS,uniProtId:Q13332-1,ncbiNodeId:9606,antigenRange:822-897,antigenLength:1948,antigenImageFileName:PA5-65894_PTPRS_Q13332-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65894_PTPRS_Q13332-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663238

Product Specific Information

Immunogen sequence: KPKVVVTKGAV LGRPTLSVQQ TPEGSLLARW EPPAGTAEDQ VLGYRLQFGR EDSTPLATLE FPPSEDRYTA SGVHK

Highest antigen sequence identity to the following orthologs - mouse 76%, rat 76%.

Target Information

PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.