Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody

Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
• Storage guidance: For short term use, store at 2–8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  • Dog: 100%
  • Guinea Pig: 93%
  • Horse: 93%
  • Human: 100%
  • Mouse: 100%
  • Pig: 100%
  • Rabbit: 86%
  • Rat: 100%

Target Information

A novel cytokine designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22 was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate the JAK-STAT signaling pathway.

IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, indicating its role in inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.