Thermo Fisher Scientific p38 MAPK alpha Polyclonal Antibody
Human 및 Mouse에서 반응하는 p38 MAPK alpha 폴리클로날 항체. Western blot 및 IHC(파라핀) 적용 가능. 비결합형 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관. 스트레스 반응 및 염증 관련 MAPK 경로 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a portion of human MAPK14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum/PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1077515 |
Product Specific Information
This antibody cross-reacts with mouse and rat MAPK14 based on sequence homology.
Suggested positive control: Human pancreas tissue or human pancreas protein.
Target Information
MAPK14 (p38 alpha) belongs to the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other stimuli.
p38 MAPK is inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation at the Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK that differ in tissue expression and affinity for upstream activators and downstream effectors.
Activation occurs upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, leading to phosphorylation by MAPK kinase-3/6 at Thr180 and Tyr182. Activated p38 MAPK then phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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