Thermo Fisher Scientific MED11 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  YSLANERLRA LEDIEREIGA ILQNAGTVIL ELSKEKTNER LLDRQAAAFT ASVQHVEAEL SAQIRYLTQV ATGQPHEGSS YSSRKDCQMA LKRVDYARLK LSDVARTCEQ MLE
• Highest antigen sequence identity to orthologs: Mouse 97%, Rat 98%

Target Information

In mammalian cells, transcription is regulated by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription.

Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and a component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes on chromosome 17 are p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. BRCA1 is directly involved in DNA repair and linked to predisposition to cancers of the ovary, colon, prostate gland, and fallopian tubes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.