Thermo Fisher Scientific CD85j (ILT2) Monoclonal Antibody (HP-F1), eFluor 450, eBioscience
CD85j(ILT2)을 인식하는 HP-F1 단클론 항체로, eFluor 450 형광체가 결합된 형광세포분석용 항체입니다. 인간 시료에 반응하며, NK 및 T세포 기능 연구에 적합합니다. 405 nm 레이저로 여기되며 445 nm에서 방출됩니다.
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Applications
- Flow Cytometry (Flow): Tested at 5 µL (0.25 µg)/test
- View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 450, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HP-F1 |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2815182 |
Additional Available Formats
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 737
- FITC
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 700
- NovaFluor Red 725
- NovaFluor Yellow 570
- NovaFluor Yellow 590
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
The monoclonal antibody HP-F1 recognizes CD85j (ILT2, LILRB1, LIR1), a member of the ILT/LIR/MIR receptor family. CD85j is a single transmembrane glycoprotein with four ITIM motifs that signal via SHP-1 interactions. It is expressed on myeloid cells (monocytes, dendritic cells) and subsets of NK, T, and B lymphocytes. Expression correlates with leukemias such as ALL and CLL and plays roles in viral infections including HIV, EBV, and CMV. Ligands include MHC Class I molecules (HLA-G, A, F, B27, E, F).
HP-F1 antibody reduces CD16-dependent cytolytic activity of NK cells.
Reported applications include flow cytometric analysis of normal human peripheral blood cells at 5 µL (0.25 µg) per test. One test corresponds to staining in a 100 µL final volume (10⁵–10⁸ cells/test).
eFluor 450 is an alternative to Pacific Blue™, excited at 405 nm and emitting at 445 nm. Ensure instrument compatibility.
- Excitation: 405 nm
- Emission: 445 nm
- Laser: Violet
Target Information
This gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family located in the 19q13.4 region. The encoded receptor contains multiple extracellular Ig domains, a transmembrane domain, and ITIM motifs that mediate inhibitory signaling upon binding MHC class I molecules. It regulates immune cell activation, inflammatory responses, and cytotoxicity to maintain immune balance. Multiple isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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