Thermo Fisher Scientific SAV1 Monoclonal Antibody (OTI2B7)

Applications and Tested Dilution

Product Specifications

Target Information

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway consists of a kinase cascade where STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylate and activate LATS1/2 with its regulatory protein MOB1. This, in turn, phosphorylates and inactivates the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its nuclear translocation, regulating genes important for cell proliferation, death, and migration. SAV1 is essential for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also contributes to centrosome disjunction by regulating NEK2 localization to centrosomes and its phosphorylation of CROCC and CEP250. Together with STK3/MST2, Sav1 activates ESR1 transcriptional activity by modulating its phosphorylation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.