Thermo Fisher Scientific NUP88 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NUP88. Recombinant protein control fragment (Product #RP-93198). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NUP88,uniProtId:Q99567-1,ncbiNodeId:9606,antigenRange:54-189,antigenLength:741,antigenImageFileName:PA5-54518_NUP88_Q99567-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54518_NUP88_Q99567-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644903

Product Specific Information

Immunogen sequence: QLLTRNVVFG LGGELFLWDG EDSSFLVVRL RGPSGGGEEP ALSQYQRLLC INPPLFEIYQ VLLSPTQHHV ALIGIKGLMV LELPKRWGKN SEFEGGKSTV NCSTTPVAER FFTSSTSLTL KHAAWYPSEI LDPHVV

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.

Target Information

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.