Thermo Fisher Scientific NUP88 Polyclonal Antibody
Human NUP88 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 기반 용액 형태로 제공됩니다. 종 특이성은 Human이며, 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NUP88. Recombinant protein control fragment (Product #RP-93198) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644903 |
Product Specific Information
Immunogen sequence:
QLLTRNVVFG LGGELFLWDG EDSSFLVVRL RGPSGGGEEP ALSQYQRLLC INPPLFEIYQ VLLSPTQHHV ALIGIKGLMV LELPKRWGKN SEFEGGKSTV NCSTTPVAER FFTSSTSLTL KHAAWYPSEI LDPHVV
Ortholog sequence identity:
- Mouse: 87%
- Rat: 86%
Target Information
The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), characterized by O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG).
Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. It is expressed ubiquitously and subject to phosphorylation by ATM or ATR. Nup88 is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis.
The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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