Thermo Fisher Scientific Involucrin Polyclonal Antibody
Thermo Fisher Scientific의 Involucrin Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot 및 ELISA에 적합합니다. KLH 결합 합성 펩타이드로부터 유래된 Rabbit IgG 항체로, Protein A로 정제되었습니다. -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Involucrin (amino acids 21–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Involucrin is a component of the keratinocyte crosslinked envelope, found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. It is expressed in various stratified squamous epithelia, including the cornea. In normal epidermis, it appears in the upper spinous layers and in keratinocyte cultures, it is expressed by cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions, and reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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