Thermo Fisher Scientific eIF4E Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Bovine and Rabbit

Target Information

eIF4E is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export.
All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide).
EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs.
It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F.
The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis.
The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.