Thermo Fisher Scientific PADI2 Polyclonal Antibody
Human PADI2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% glycerol 포함)로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PADI2. Recombinant protein control fragment (Product #RP-103009). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645162 |
Product Specific Information
Immunogen sequence:
PWLPKEDCRD EKVYSKEDLK DMSQMILRTK GPDRLPAGYE IVLYISMSDS DKVGVFYVEN PFFGQRYIHI LGRRKLYHVV KYTGGS
Antigen sequence identity:
- Mouse: 95%
- Rat: 95%
Target Information
This gene encodes a member of the peptidyl arginine deiminase (PADI) family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions.
The type II enzyme (PADI2) is the most widely expressed family member, with known substrates including myelin basic protein in the CNS and vimentin in skeletal muscle and macrophages.
It is implicated in neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis, and glaucoma pathogenesis.
This gene exists in a cluster with four other paralogous genes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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