Thermo Fisher Scientific PADI2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PADI2. Recombinant protein control fragment (Product #RP-103009). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PADI2,uniProtId:Q9Y2J8-1,ncbiNodeId:9606,antigenRange:160-245,antigenLength:665,antigenImageFileName:PA5-61579_PADI2_Q9Y2J8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61579_PADI2_Q9Y2J8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645162

Product Specific Information

Immunogen sequence: PWLPKEDCRD EKVYSKEDLK DMSQMILRTK GPDRLPAGYE IVLYISMSDS DKVGVFYVEN PFFGQRYIHI LGRRKLYHVV KYTGGS

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.