Thermo Fisher Scientific ELL Monoclonal Antibody (OTI1C12), TrueMAB
ELL 단백질을 표적하는 마우스 모노클로날 항체로, WB 및 IHC(P)에서 검증됨. 인간 시료에 반응하며, TrueMAB 형식의 고순도 항체. RNA polymerase II/III 전사 조절 연구용으로 적합. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 302–621 of human ELL produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Also a component of the little elongation complex (LEC), which regulates small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription.
ELL plays an early role before its assembly into the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site, and is required to stabilize the pre-initiation complex and early elongation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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