Thermo Fisher Scientific CD4 Monoclonal Antibody (S3.5), PE-Cyanine7

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent
• Publications: View 5 publications

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 405
• Alexa Fluor 488
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• APC-Cyanine5.5
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Alexa Fluor 700
• PE-Cyanine5.5
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• Qdot 800
• TRI-COLOR
• Custom conjugation available upon request

Product Specific Information

The R-phycoerythrin (PE)-Cy7 tandem conjugate enables simultaneous multicolor labeling and detection of multiple targets using excitation by a 488 nm laser, without occupying traditional channels associated with FITC and PE.

Target Information

CD4 antigen is involved in the recognition of MHC class II molecules and serves as a co-receptor for HIV. It is primarily expressed in T helper cells but can also be found in monocytes, macrophages, and dendritic cells. At the tissue level, CD4 is expressed in thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut. CD4 functions to initiate or augment early T-cell activation via association with the T-cell receptor complex and protein tyrosine kinase Lck. It may also mediate neuronal damage in infectious and immune-mediated CNS diseases. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

Analyte Specific Reagent

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