Thermo Fisher Scientific Grp94 Monoclonal Antibody (9G10)
Grp94 단백질을 인식하는 Rat 모노클로날 항체로, 다양한 종에 반응하며 Western Blot, IHC, ICC/IF, IP 등에 사용 가능. 단백질 A로 정제된 액상 형태이며 PBS 버퍼에 저장. 연구용으로만 사용.
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Thermo Fisher Scientific Grp94 Monoclonal Antibody (9G10)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2–30 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Guinea pig, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat, Xenopus |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9G10 |
| Immunogen | Purified Grp94 isolated from chicken oviducts |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family.
It acts as a molecular chaperone involved in processing and transport of secreted proteins.
GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC).
It plays a central role in innate and acquired immunity, dendritic cell maturation and chemotaxis, antibody production, and cross-priming.
GRP94 serves as a potential marker in breast cancer and functions as a peptide acceptor in the endoplasmic reticulum, assisting peptide loading of MHC class I molecules.
Expression of GRP94 suppresses A23187-induced apoptosis and stabilizes calcium homeostasis.
It is expressed in melanoma, liver metastases of colon carcinoma cells, and human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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