Thermo Fisher Scientific Phospho-Cyclin B3 (Ser277) Polyclonal Antibody

Applications

• Dot blot (DB): Tested dilution 1:1,000

Product Specifications

Target Information

Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes.
The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity.
Cyclin B3 (also known as CCNB3 or CYCB3) is a 1,395 amino acid nuclear protein belonging to the cyclin family of regulatory proteins. It is expressed predominantly in testis with lower expression in other tissues and is thought to be required for early meiotic prophase I, playing an important role in the meiotic cell cycle. Three isoforms of cyclin B3 exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.