
Thermo Fisher Scientific NeuroG3 Monoclonal Antibody (OTI5A8), TrueMAB
NeuroG3 단백질을 인식하는 마우스 단클론 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 동결건조 형태로 제공되며 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 내분비 세포 분화 연구에 유용하며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A8 |
| Immunogen | Recombinant fragment expressed in E. coli corresponding to amino acids 1–214 of human Ngn3 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
NeuroG3 protein contains one basic helix-loop-helix (bHLH) domain. It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors.
Neurogenin 3 not only initiates endocrine cell differentiation but also promotes islet cell maturation and maintains islet function. It has been reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors toward endocrine rather than goblet cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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