Thermo Fisher Scientific Major Vault Protein (MVP) Recombinant Rabbit Monoclonal Antibody (VP2897R)
Recombinant rabbit monoclonal antibody targeting human Major Vault Protein (MVP). Validated for IHC (paraffin) applications at 1–2 µg/mL. Unconjugated, purified via Protein A/G, supplied in PBS without preservative. Ideal for studying drug resistance a...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | VP2897R |
| Immunogen | Recombinant full-length human MVP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C (preferred) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
The Major Vault Protein (MVP) gene encodes a lung resistance-related protein. Vaults are multi-subunit structures potentially involved in nucleo-cytoplasmic transport. MVP mediates drug resistance, possibly through a transport process, and is widely distributed in normal tissues. It is overexpressed in multidrug-resistant cancer cells, making it a useful marker for clinical drug resistance. Two transcripts are produced using alternative exon 2 sequences, sharing identical open reading frames.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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