Thermo Fisher Scientific DAF Monoclonal Antibody (1D7)
Thermo Fisher Scientific DAF Monoclonal Antibody (1D7)은 인간 CD55(DAF)를 인식하는 Mouse IgG1 단일클론 항체입니다. Western blot, ICC/IF, ELISA 등 다양한 응용에 적합하며, PBS 기반의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D7 |
| Immunogen | DAF (NP_000565, 35 a.a. approximately 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DCGLPPDVPN AQPALEGRTS FPEDTVITYK CEESFVKIPG EKDSVICLRG SQWSDIEEFC NRSCEVPTRL NSASLKQPYI TQNYFPVGTV VEYECRPGYR
Target Information
CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathways of the complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation, and CD55 can regulate complement when bound to CD97.
In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness, and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by a glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger and contains substantial O-glycans.
CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing assembly and accelerating decay of both classical and alternative pathways. CD55 carries Cromer-related blood group antigens. Two alternatively spliced transcripts encode CD55: a predominant membrane-bound form and a soluble form expressed at lower levels.
CD55 has been studied for its role in prostate cancer growth and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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