Thermo Fisher Scientific DAF Monoclonal Antibody (1D7)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
DCGLPPDVPN AQPALEGRTS FPEDTVITYK CEESFVKIPG EKDSVICLRG SQWSDIEEFC NRSCEVPTRL NSASLKQPYI TQNYFPVGTV VEYECRPGYR

Target Information

CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathways of the complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation, and CD55 can regulate complement when bound to CD97.

In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness, and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by a glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger and contains substantial O-glycans.

CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing assembly and accelerating decay of both classical and alternative pathways. CD55 carries Cromer-related blood group antigens. Two alternatively spliced transcripts encode CD55: a predominant membrane-bound form and a soluble form expressed at lower levels.

CD55 has been studied for its role in prostate cancer growth and survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.