Thermo Fisher Scientific DAG1 Monoclonal Antibody (2A3)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
WPSEPSEAVR DWENQLEASM HSVLSDLHEA VPTVVGIPDG TAVVGRSFRV TIPTDLIASS GDIIKVSAAG KEALPSWLHW DSQSHTLEGL PLDTDKGVHY ISVSATRLGA

Target Information

Dystroglycan is a laminin-binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix.
Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies.
The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis.
Dystroglycan also functions as a dual receptor for agrin and laminin-2 in the Schwann cell membrane.
The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence.
Alternative splicing results in multiple transcript variants all encoding the same protein.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.