Thermo Fisher Scientific BNIP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 125-280 of human BNIP2 (NP_0043212) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BNIP2,uniProtId:Q12982-1,ncbiNodeId:9606,antigenRange:125-280,antigenLength:314,antigenImageFileName:PA5-92864_BNIP2_Q12982-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92864_BNIP2_Q12982-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.67 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806523

Product Specific Information

Immunogen sequence: VELKEEWQDE DFPIPLPEDD SIEADILAIT GPEDQPGSLE VNGNKVRKKL MAPDISLTLD PSDGSVLSDD LDESGEIDLD GLDTPSENSN EFEWEDDLPK PKTTEVIRKG SITEYTAAEE KEDGRRWRMF RIGEQDHRVD MKAIEPYKKV ISHGGY; Positive Samples: U-937, SW480, NCI-H460, Mouse heart; Cellular Location: Cytoplasm, perinuclear region

Target Information

BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.